Author/Authors :
Chen Zhao، نويسنده , , Hing L. Sham، نويسنده , , MingHua Sun، نويسنده , , Vincent S. Stoll، نويسنده , , Kent D. Stewart، نويسنده , , Shuqun Lin، نويسنده , , Hongmei Mo، نويسنده , , Sudthida Vasavanonda، نويسنده , , Ayda Saldivar، نويسنده , , Chang Park، نويسنده , , Edith J. McDonald، نويسنده , , Kennan C. Marsh، نويسنده , , Larry L. Klein، نويسنده , , Dale J. Kempf، نويسنده , , Daniel W. Norbeck، نويسنده ,
Abstract :
As part of our efforts to identify potent HIV-1 protease inhibitors that are active against resistant viral strains, structural modification of the azacyclic urea (I) was undertaken by incorporating acyl groups as P1′ ligands. The extensive SAR study has yielded a series of N-acyl azacyclic ureas (II), which are highly potent against both wild-type and multiple PI-resistant viral strains.
