Title of article
Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains
Author/Authors
Chen Zhao، نويسنده , , Hing L. Sham، نويسنده , , MingHua Sun، نويسنده , , Vincent S. Stoll، نويسنده , , Kent D. Stewart، نويسنده , , Shuqun Lin، نويسنده , , Hongmei Mo، نويسنده , , Sudthida Vasavanonda، نويسنده , , Ayda Saldivar، نويسنده , , Chang Park، نويسنده , , Edith J. McDonald، نويسنده , , Kennan C. Marsh، نويسنده , , Larry L. Klein، نويسنده , , Dale J. Kempf، نويسنده , , Daniel W. Norbeck، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
5499
To page
5503
Abstract
As part of our efforts to identify potent HIV-1 protease inhibitors that are active against resistant viral strains, structural modification of the azacyclic urea (I) was undertaken by incorporating acyl groups as P1′ ligands. The extensive SAR study has yielded a series of N-acyl azacyclic ureas (II), which are highly potent against both wild-type and multiple PI-resistant viral strains.
Keywords
HIV-1 protease inhibitor , Resistant viral strain , N-Acyl azacyclic urea
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796216
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