Title of article :
Surfing the piperazine core of tricyclic farnesyltransferase inhibitors
Author/Authors :
Laura L. Rokosz، نويسنده , , Chia-Yu Huang، نويسنده , , John C. Reader، نويسنده , , Tara M. Stauffer، نويسنده , , Daniel Chelsky، نويسنده , , Nolan H. Sigal، نويسنده , , Ashit K. Ganguly، نويسنده , , John J. Baldwin، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
In order to fully explore structure–activity relationships at the 1- and 2-positions of the piperazine core of tricyclic farnesyltransferase inhibitors, an 11,718-member ECLiPS® library was synthesized and screened in a farnesyltransferase scintillation proximity assay. A detailed description of the library and analyses of the screening data will be provided.
Keywords :
ECLiPS® , High-throughput screening , Farnesyltransferase inhibitors , Anti-cancer , Scintillation proximity assay (SPA) , combinatorial chemistry
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
