Title of article
Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK
Author/Authors
Rudolf Waelchli، نويسنده , , Birgit Bollbuck، نويسنده , , Christian Bruns، نويسنده , , Thomas Buhl، نويسنده , , J?rg Eder، نويسنده , , Roland Feifel، نويسنده , , Rene Hersperger، نويسنده , , Philipp Janser، نويسنده , , Laszlo Revesz، نويسنده , , Hans-Günter Zerwes، نويسنده , , Achim Schlapbach، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
108
To page
112
Abstract
The design, synthesis, and the biological evaluation of 2-benzamido-pyrimidines as novel IKK inhibitors are described. By optimization of the lead compound 3, compounds 16 and 24 are identified as good inhibitors of IKK2 with IC50 values of 40 and 25 nM, respectively. Compound 16 also demonstrated significant in vivo activity in an acute model of cytokine release.
Keywords
IKK2 , IKK inhibitors , In vivo activity , 2-Benzamido-pyrimidines
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796324
Link To Document