Title of article
Biological evaluation of 1-alkyl-3-phenylthioureas as orally active HDL-elevating agents
Author/Authors
Gary M. Coppola، نويسنده , , Robert E. Damon، نويسنده , , J. Bruce Eskesen، نويسنده , , Dennis S. France، نويسنده , , James R. Paterniti Jr.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
113
To page
117
Abstract
A series of 1-alkyl-3-phenylthiourea analogues were prepared and evaluated as HDL- and Apo A-I-elevating and triglyceride-lowering agents. Several derivatives were superior to gemfibrozil (1). The optimal analogue 8d (HDL376) was shown to raise HDL cholesterol in the rat, hamster, dog, and monkey models.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796325
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