Title of article
Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection
Author/Authors
Andrew Burchat، نويسنده , , Alexandre P. Kuzin and David W. Borhani، نويسنده , , David J. Calderwood، نويسنده , , Gavin C. Hirst، نويسنده , , Biqin Li، نويسنده , , Robert F. Stachlewitz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
118
To page
122
Abstract
We describe the identification, SAR, and pharmacology of the src-family selective lck inhibitor A-770041 that prolongs the survival of major histocompatibility mismatched allografts in models of solid organ transplant rejection for greater than 65 days.
Keywords
Lck inhibitor , Src-family , kinase inhibitor , Transplant rejection
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796326
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