Title of article
Synthesis of a novel biotin-tagged photoaffinity probe for VEGF receptor tyrosine kinases
Author/Authors
Sun-young Han، نويسنده , , Seok Soon Park، نويسنده , , Woo Ghil Lee، نويسنده , , Yong Ki Min، نويسنده , , Bum Tae Kim، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
129
To page
133
Abstract
A novel biotin-tagged photoaffinity probe was synthesized and evaluated as a vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase inhibitor. The probe (2) is a potent VEGFR-2 inhibitor with an IC50 value of 7.1 μM, and inhibits VEGF-induced proliferation in human umbilical vein endothelial cells (HUVEC), with an IC50 value of 40.3 μM. This probe will be a useful reagent for investigating ligand–protein interactions.
Keywords
Vascular endothelial growth factor receptors , inhibitor , Biotin-tagged photoaffinity probe , Ligand–protein interactions
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796328
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