Title of article
The structure–activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs
Author/Authors
Young-Ger Suh، نويسنده , , Sun Nam Kim، نويسنده , , Dong-Yun Shin، نويسنده , , Soon-Sil Hyun، نويسنده , , Do-Sang Lee، نويسنده , , Kyung-Hoon Min، نويسنده , , Sae Mi Han، نويسنده , , Funan Li، نويسنده , , Eung-Chil Choi، نويسنده , , Seong-Hak Choi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
142
To page
145
Abstract
For the systematic SAR study on mansonone F, a series of C6 and C9 analogs of mansonone F have been synthesized and their anti-MRSA activities were evaluated. Most of the analogs exhibited good or excellent anti-MRSA activities. In particular, the 6-n-butylmansonone F showed fourfold higher antibacterial activities compared to that of vancomycin.
Keywords
Mansonone F , Anti-bacterial agent , MRSA , Sesquiterpenoid quinone
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796331
Link To Document