Author/Authors :
Schuyler Antane، نويسنده , , Craig E. Caufield، نويسنده , , William Hu، نويسنده , , David Keeney، نويسنده , , Pornpen Labthavikul، نويسنده , , Koi Morris، نويسنده , , Shaughnessy M. Naughton، نويسنده , , Peter J. Petersen، نويسنده , , Beth A. Rasmussen، نويسنده , , Guy Singh، نويسنده , , Youjun Yang، نويسنده ,
Abstract :
Pulvinones were synthesized (>180) in arrays and evaluated as inhibitors of early stage cell wall biosynthesis enzymes MurA–MurD. Several pulvinones inhibited Mur enzymes with IC50’s in the 1–10 μg/mL range and demonstrated antibacterial activity against Gram-positive bacteria including methicillin-resistant Staphyloccus aureus, vancomycin-resistant Enterococcus faecalis, and penicillin-resistant Streptococcus pneumoniae.
Keywords :
Pulvinones , Murein enzyme inhibitors , Antibacterial , Microwave demethylation
