Title of article
Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 (1), and the discovery of posaconazole [Sch 56592; 2 or (S,S)-5]
Author/Authors
Frank Bennett، نويسنده , , Anil K. Saksena، نويسنده , , Raymond G. Lovey، نويسنده , , Yi-Tsung Liu، نويسنده , , Naginbhai M. Patel، نويسنده , , Patrick Pinto، نويسنده , , Russel Pike، نويسنده , , Edwin Jao، نويسنده , , Viyyoor M. Girijavallabhan، نويسنده , , Ashit K. Ganguly، نويسنده , , David Loebenberg، نويسنده , , Haiyan Wang، نويسنده , , Anthony Cacciapuoti، نويسنده , , Eugene Moss Jr.، نويسنده , , Fred Menzel، نويسنده , , Roberta S. Hare، نويسنده , , Amin Nomeir، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
186
To page
190
Abstract
As part of a detailed study, the syntheses, biological activities, and pharmacokinetic properties of hydroxylated analogues of the previously described broad spectrum antifungal agents, Sch 51048 (1), Sch 50001 (3), and Sch 50002 (4), are described. Based on an overall superior profile, one of the alcohols, Sch 56592 (2), was selected for clinical studies.
Keywords
Antifungal , Posaconazole
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796341
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