Title of article
Synthesis and antiviral activity of 7-deazaneplanocin A against orthopoxviruses (vaccinia and cowpox virus)
Author/Authors
Balakumar Arumugham، نويسنده , , Hyo-Joong Kim، نويسنده , , Mark N. Prichard، نويسنده , , Earl R. Kern، نويسنده , , Chung K. Chu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
3
From page
285
To page
287
Abstract
An efficient method for the synthesis of 7-deazaneplanocin A (2) has been accomplished by the condensation of cyclopentenol 3 with 6-chloro-7-deazapurine followed by subsequent functional group manipulations. The synthesized 7-deazaneplanocin A (2) exhibited potent antiviral activity against cowpox and vaccinia viruses without cytotoxicity in HFF cells.
Keywords
7-Deazaneplanocin A , Vaccinia , Cowpox , Orthopoxviruses
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796360
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