Title of article
Potent anti-muscarinic activity in a novel series of quinuclidine derivatives
Author/Authors
Jean-Philippe Starck، نويسنده , , Patrice Talaga، نويسنده , , Luc Quéré، نويسنده , , Philippe Collart، نويسنده , , Bernard Christophe، نويسنده , , Patrick Lo Brutto، نويسنده , , Sophie Jadot، نويسنده , , Dinesh Chimmanamada، نويسنده , , Matteo Zanda، نويسنده , , Alain Wagner، نويسنده , , Charles Mioskowski، نويسنده , , Roy Massingham، نويسنده , , Michel Guyaux، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
373
To page
377
Abstract
The synthesis and biological evaluation of a novel family of M3 muscarinic antagonists are described. A systematic modification of the substituents to a novel alkyne-quinuclidine scaffold yielded original compounds displaying potent in vitro anticholinergic properties.
Keywords
Muscarinic receptor(s) , bladder , Urinary incontinence , Quinuclidine , Muscarinic antagonist(s) , Overactive bladder
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796378
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