Title of article
Synthesis and antibacterial activity of 9-substituted minocycline derivatives
Author/Authors
Phaik-Eng Sum، نويسنده , , Adma T. Ross، نويسنده , , Peter J. Petersen، نويسنده , , Raymond T. Testa، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
400
To page
403
Abstract
A number of 9-acylamino and 9-sulfonylamino derivatives of minocycline have been synthesized for structure–activity relationship studies. These compounds showed activity against both tetracycline-susceptible and tetracycline-resistant strains. Many of the 9-sulfonylamino derivatives exhibited improved antibacterial activity against a number of tetracycline- and minocycline-resistant Gram-positive pathogens.
Keywords
Novel tetracyclines , antibiotic , resistant bacteria
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796384
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