Title of article
In silico design and synthesis of piperazine-1-pyrrolidine-2,5-dione scaffold-based novel malic enzyme inhibitors
Author/Authors
Y. John Zhang، نويسنده , , Zhaolin Wang، نويسنده , , Dennis Sprous، نويسنده , , Roustem Nabioullin، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
525
To page
528
Abstract
Fragment-based virtual library design and virtual screening have been conducted against malic enzyme (ME) homology model. Several scaffolds have been identified as promising motifs to target ME’s NADP binding site. One small focused library has been synthesized and tested against ME. Several compounds from this library have shown sub-micromolar inhibitory activity against malic enzyme.
Keywords
Enzyme inhibitor design , Virtual screening
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796408
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