Title of article :
The design and synthesis of YC-1 analogues as probes for soluble guanylate cyclase
Author/Authors :
Kirk W. Hering، نويسنده , , Jennifer D. Artz، نويسنده , , William H. Pearson، نويسنده , , Michael A. Marletta، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
Soluble guanylate cyclase (sGC) is highly activated in the presence of both YC-1 (1-benzyl-3-(5′-hydroxymethyl-2′-furyl)-indazole) and CO. In this report, the design, synthesis, and activity (i.e., sGC activation) of photolabile analogues of 3-(5′-hydroxymethyl-2′-furyl)-1-benzylindazole (YC-1) are presented. Initial results with 6-azido-3-(5′-hydroxymethyl-2′-furyl)-1-benzylindazole led to the synthesis of a tritium-labeled analogue. When photoactivated, this analogue labeled the α-subunit of sGC.
Keywords :
Soluble guanylate cyclase , nitric oxide , YC-1
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters