Author/Authors :
Ji-Feng Liu، نويسنده , , Christopher J. Wilson، نويسنده , , Lie-ping Ye، نويسنده , , Kevin Sprague، نويسنده , , Katie Sargent، نويسنده , , Ying Si، نويسنده , , Galina Beletsky، نويسنده , , Daniel Yohannes، نويسنده , , Shi-Chung Ng، نويسنده ,
Abstract :
A focused quinazolinone natural product-templated library was designed and synthesized. Compounds from this privileged structure-based library were identified as antimitotic agents acting through destabilization of tubulin polymerization. The results suggested that 2 could be a privileged substructure.
Keywords :
Privileged structure , Quinazolinone , Tubulin polymerization inhibitors , Natural product-templated library
