Title of article :
Pentacyclic triterpenes. Part 2: Synthesis and biological evaluation of maslinic acid derivatives as glycogen phosphorylase inhibitors
Author/Authors :
Xiaoan Wen، نويسنده , , Pu Zhang، نويسنده , , Jun Liu، نويسنده , , Luyong Zhang، نويسنده , , Xiaoming Wu، نويسنده , , Peizhou Ni، نويسنده , , Hongbin Sun، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
The synthesis of a series of maslinic acid derivatives is described and their effect on rabbit muscle glycogen phosphorylase a evaluated. Within this series of compounds, 15 (IC50 = 7 μM) is the most potent GPa inhibitor. SAR of the maslinic acid derivatives are discussed.
Keywords :
Maslinic acid , derivatives , SAR , Glycogen phosphorylase , inhibitor , synthesis
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
