Title of article
Hydrolysis of plasmid DNA and RNA by amino alkyl naphthalimide as metal-free artificial nuclease
Author/Authors
Qing Yang، نويسنده , , Jianqiang Xu، نويسنده , , Yuanshe Sun، نويسنده , , Zhigang Li، نويسنده , , Yonggang Li، نويسنده , , Xuhong Qian، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
803
To page
806
Abstract
A strategy of dimethylamino alkyldiimide conjugated with an intercalator of naphthalimide for hydrolysis of DNA was suggested and evaluated. 4 can hydrolyze 4 kb plasmid DNA into 2 kb fragments with GC and GG selectivity, which represents a novel example of sequence- or site-selective metal-free DNA artificial nuclease. Results also show it could hydrolyze RNA efficiently.
Keywords
DNA cleavage , Hydrolysis , naphthalimide , Intercalator , Selectivity , RNA
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796464
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