Title of article
Synthesis and structure–activity relationships of a new series of 2α-substituted trans-4,5-dimethyl-4-(3-hydroxyphenyl)piperidine as μ-selective opioid antagonists
Author/Authors
Bertrand Le Bourdonnec، نويسنده , , Allan J. Goodman، نويسنده , , Mathieu Michaut، نويسنده , , Hai-Fen Ye، نويسنده , , Thomas M. Graczyk، نويسنده , , Serge Belanger، نويسنده , , Robert N. DeHaven، نويسنده , , Roland E. Dolle، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
864
To page
868
Abstract
Structure–activity relationships at the 2α-position of the piperidine ring of the trans-4,5-dimethyl-4-(3-hydroxyphenyl)piperidine μ-opioid antagonist series were investigated. This study showed that only small linear alkyl groups (methyl, propyl) are tolerated at the 2α-position of the piperidine ring of this series.
Keywords
Opioid , Antagonist , ?
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796477
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