Title of article
Novel non-nucleobase inhibitors of Staphylococcus aureus DNA polymerase IIIC
Author/Authors
Yannick Rose، نويسنده , , Stéphane Ciblat، نويسنده , , S. Ranga Reddy and P. Manikyamba، نويسنده , , Adam C. Belley، نويسنده , , Evelyne Dietrich، نويسنده , , Dario Lehoux، نويسنده , , Geoffrey A. McKay، نويسنده , , Hugo Poirier، نويسنده , , Adel Rafai Far، نويسنده , , Daniel Delorme، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
6
From page
891
To page
896
Abstract
The preparation and biological evaluation of 5-substituted-6-hydroxy-2-(anilino)pyrimidinones as a new class of DNA polymerase IIIC inhibitors, required for the replication of chromosomal DNA in Gram-positive bacteria, are described. These new dGTP competitive inhibitors displayed good levels of in vitro inhibition and antibacterial activity against Staphylococcus aureus. A new class of dATP competitive inhibitors, 6-substituted-2-amino-5-alkyl-pyrimidin-4-ones, whose antibacterial activity was unaffected by serum, were identified.
Keywords
antimicrobial , Antibacterial , DNA polymerase IIIC , In Vivo , Protein binding
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796484
Link To Document