Title of article :
Design, synthesis, and evaluation of 2-alkoxydihydrocinnamates as PPAR agonists
Author/Authors :
Ying Lu، نويسنده , , Zongru Guo، نويسنده , , Yanshen Guo، نويسنده , , Jun Feng، نويسنده , , Fengming Chu، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
A series of 2-alkoxydihydrocinnamates were synthesized as PPARγ and PPARα dual agonists. In vitro studies in cell model showed that these compounds were efficacious. Compound 1g was found to be a potent PPARα/γ dual agonist and will be further evaluated for the treatment of type II diabetes.
Keywords :
Antidiabetes , 2-Alkoxydihydrocinnamates , PPAR agonists
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
