Title of article
Synthesis and evaluation of 2-anilino-3-phenylsulfonyl-6-methylpyridines as corticotropin-releasing factor1 receptor ligands
Author/Authors
Richard A. Hartz، نويسنده , , Argyrios G. Arvanitis، نويسنده , , Charles Arnold، نويسنده , , Joseph P. Rescinito، نويسنده , , Kimberly L. Hung، نويسنده , , Ge Zhang، نويسنده , , Harvey Wong، نويسنده , , David R. Langley، نويسنده , , Paul J. Gilligan، نويسنده , , George L. Trainor، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
934
To page
937
Abstract
A novel series of 2-anilino-3-phenylsulfonyl-6-methylpyridines was synthesized and evaluated as corticotropin-releasing factor receptor ligands. Structure–activity relationship studies focused primarily on optimization of the 3-phenylsulfonyl group. Compounds within this series were identified which showed potent binding affinity for the CRF1 receptor. Selected compounds were examined in a rat pharmacokinetic study and were found to have oral bioavailabilities ranging from 16 to 35%.
Keywords
Corticotropin-releasing factor , Phenylsulfone , CRF
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796493
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