Title of article
Pyridobenzodiazepines: A novel class of orally active, vasopressin V2 receptor selective agonists
Author/Authors
Amedeo A. Failli، نويسنده , , Jay S. Shumsky، نويسنده , , Robert J. Steffan، نويسنده , , Thomas J. Caggiano، نويسنده , , David K. Williams، نويسنده , , Eugene J. Trybulski، نويسنده , , Xiaoping Ning، نويسنده , , Yeungwai Lock، نويسنده , , Tarak Tanikella، نويسنده , , David Hartmann، نويسنده , , Peter S. Chan، نويسنده , , C.H. Park، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
6
From page
954
To page
959
Abstract
Our efforts in seeking low molecular weight agonists of the antidiuretic peptide hormone arginine vasopressin (AVP) have led to the identification of the clinical candidate WAY-151932 (VNA-932). Further exploration of the structural requirements for agonist activity has provided another class of potent, orally active, non-peptidic vasopressin V2 receptor selective agonists exemplified by the 5,11-dihydro-pyrido[2,3-b][1,5]benzodiazepine as a candidate for further development.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796497
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