Title of article
Hit-to-Lead studies: The discovery of potent, orally bioavailable thiazolopyrimidine CXCR2 receptor antagonists
Author/Authors
Andrew Baxter، نويسنده , , Anne Cooper Moore، نويسنده , , Elizabeth Kinchin، نويسنده , , Kerry Moakes، نويسنده , , John Unitt، نويسنده , , Alan Wallace، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
960
To page
963
Abstract
A Hit-to-Lead optimisation programme was carried out on a high throughput screening hit, the thiazolopyrimidine 1, resulting in the discovery of the potent, orally bioavailable CXCR2 antagonist 29.
Keywords
Hit-to-Lead , CXCR2 antagonist
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796498
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