Title of article
Intermolecular interactions in the crystal structures of potential HIV-1 integrase inhibitors
Author/Authors
Katarzyna Majerz-Maniecka، نويسنده , , Robert Musiol، نويسنده , , Wojciech Nitek، نويسنده , , Barbara J. Oleksyn، نويسنده , , Jean-François Mouscadet، نويسنده , , Marc Le Bret، نويسنده , , Jaroslaw Polanski، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
1005
To page
1009
Abstract
2-[(2,5-dichloro-4-nitro-phenylamino)-methoxy-methyl]-8-hydroxy-quinoline 1 and 2-methyl-quinoline-5,8-dione-5-oxime 2 were obtained as potential HIV-1 integrase inhibitors and analyzed by X-ray crystallography. Semiempirical theoretical calculations of energy preferred conformations were also carried out. The crystal structures of both compounds are stabilized via hydrogen bonds and π–π stacking interactions. The planarity of compound 1 is caused by intramolecular hydrogen bonds.
Keywords
Quinoline , HIV-1 integrase inhibitor , crystal structure
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796507
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