Title of article :
Conformational constraint in oxazolidinone antibacterials. Part 2: Synthesis and structure–activity studies of oxa-, aza-, and thiabicyclo[3.1.0]hexylphenyl oxazolidinones
Author/Authors :
Adam R. Renslo، نويسنده , , Hongwu Gao، نويسنده , , Priyadarshini Jaishankar، نويسنده , , Revathy Venkatachalam، نويسنده , , Marcela Gomez، نويسنده , , Johanne Blais، نويسنده , , Michael Huband، نويسنده , , J.V.N. Vara Prasad، نويسنده , , Mikhail F. Gordeev، نويسنده ,
Abstract :
A new class of oxazolidinone antibacterials incorporating oxygen-, nitrogen-, or sulfur-containing heterobicyclic C-rings is described. The in vitro potency and in vivo efficacy of these conformationally constrained oxazolidinone analogs are discussed.
