Title of article
Phenyl ureas of creatinine as mGluR5 antagonists. A structure–activity relationship study of fenobam analogues
Author/Authors
Andreas W?llberg، نويسنده , , Karolina Nilsson، نويسنده , , Krister ?sterlund، نويسنده , , Alecia Peterson، نويسنده , , Susanne Elg، نويسنده , , Patrick Raboisson، نويسنده , , Udo Bauer، نويسنده , , Lance G. Hammerland، نويسنده , , Jan P. Mattsson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
1142
To page
1145
Abstract
Fenobam (1) was developed by McNeil Laboratories as an anxiolytic agent with an unknown molecular target in the late 1970s. In a recent publication, it was revealed that fenobam is a non-competitive mGluR5 antagonist. Herein, we present the structure–activity relationship of fenobam and its analogues and similarities between the SAR of mGluR5 antagonism and the SAR of CNS properties originally reported by McNeil are discussed.
Keywords
Anxiolytic , Fenobam , Metabotropic Glutamate Receptor , mGluR5
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796531
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