Title of article
Synthesis and DNA-binding ability of pyrrolo[2,1-c][1,4]benzodiazepine-azepane conjugates
Author/Authors
Ahmed Kamal، نويسنده , , D. Rajasekhar Reddy، نويسنده , , P.S. Murali Mohan Reddy، نويسنده , , Rajendar، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
1160
To page
1163
Abstract
A series of pyrrolobenzodiazepine–azepane conjugates linked through different alkane spacers have been prepared and their DNA thermal denaturation studies have been carried out. One of the compound (4b), elevates the DNA helix melting temperature of the CT-DNA by 2.0 °C after incubation for 36 h at 37 °C.
Keywords
Pyrrolobenzodiazepine , DNA-binding ability , Hydroxyazepane
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796535
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