A topological function based on spectral moments for predicting affinity toward A3 adenosine receptors

The spectral moment descriptors have been applied to the study of affinity for A3adenosine receptors of 32 adenosine analogues. A model, able to describe more than 95% of the variance in the experimental activity, was developed with the use of the above-mentioned approach. The fragment contributions to the activity carried out show that the sulfonamido moiety at the N6 position and hydrogen bonding play an important role in the interaction with the receptor.