Title of article
Synthesis and biological evaluation of simplified mycothiazole analogues
Author/Authors
Graciela Mahler، نويسنده , , Gloria Serra، نويسنده , , Sylvia Dematteis، نويسنده , , Jenny Salda?a، نويسنده , , Laura Dom?nguez، نويسنده , , Eduardo Manta، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
3
From page
1309
To page
1311
Abstract
Thiazoline and oxazoline analogues of the natural product mycothiazole were synthesized from a common intermediate and evaluated in vitro against HCT-15 colon cancer cells and L4 larvae of nematode Nippostrongylus brasiliensis. The nature of the heterocyclic moiety seems to modulate the cytotoxic or anthelmintic activity.
Keywords
Mycothiazole , Oxazolines , anthelmintic , HTC-15 colon cells , Thiazolines , Deoxo-Fluor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796566
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