Title of article
Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase
Author/Authors
Radim Nencka، نويسنده , , Ivan Votruba، نويسنده , , Hubert H?ebabeck?، نويسنده , , Eva Tlou?t’ov?، نويسنده , , Kv?ta Horsk?، نويسنده , , Milena Masoj?dkov?، نويسنده , , Anton?n Hol?، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
3
From page
1335
To page
1337
Abstract
We report on a series of novel 5,6-disubstituted uracils with significant inhibitory activity against human and Escherichia coli thymidine phosphorylases. Bis-uracil conjugates were identified as the most potent inhibitors of TPs in this study.
Keywords
Thymidine phosphorylase inhibitor , Disubstituted uracils , angiogenesis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796572
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