Author/Authors :
Fabrizio Micheli، نويسنده , , Paolo Cavanni، نويسنده , , Romano Di Fabio، نويسنده , , Carla Marchioro، نويسنده , , Daniele Donati، نويسنده , , Stefania Faedo، نويسنده , , Micaela Maffeis، نويسنده , , Fabio Maria Sabbatini، نويسنده , , Maria Elvira Tranquillini، نويسنده ,
Abstract :
Exploiting the SAR of the known pyrrole derivatives, a new class of mGluR1 antagonists was developed through a cyclization of the C-2 position on the pyrrole N-1 nitrogen. The resulting pyrrolo[1,2-a]pyrazinones are potent and noncompetitive antagonists.
Keywords :
mGluR1 , pyrrole , Antagonist , Excitatory amino acids , Metabotropic
