Title of article
Design and synthesis of a novel, achiral class of highly potent and selective, orally active neurokinin-1 receptor antagonists
Author/Authors
Torsten Hoffmann، نويسنده , , Michael B?s، نويسنده , , Heinz Stadler، نويسنده , , Patrick Schnider، نويسنده , , Walter Hunkeler، نويسنده , , Thierry Godel، نويسنده , , Guido Galley، نويسنده , , Theresa M. Ballard، نويسنده , , Guy A. Higgins، نويسنده , , Sonia M. Poli، نويسنده , , Andrew J. Sleight، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
1362
To page
1365
Abstract
The discovery of a novel, achiral pyridine class of potent and orally active neurokinin-1 (NK1) receptor antagonists is described. The evaluation of this class is briefly outlined, leading to the identification of netupitant 21 and befetupitant 29, two new proprietary chemical entities with high affinity and excellent CNS penetration.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796579
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