Title of article
Synthesis and antihyperglycemic evaluation of various protoberberine derivatives
Author/Authors
Xiaoli Bian، نويسنده , , Langchong He، نويسنده , , Guangde Yang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
1380
To page
1383
Abstract
Various berberine derivatives (2–17) were synthesized and their antihyperglycemic activities were evaluated in a model of β-cell-membrane chromatography and a model of alloxan-induced diabetes mice. The results indicated that compounds 5 and 14 exhibited antihyperglycemic activity. Their structure–activity relationships were discussed.
Keywords
Protoberberine derivatives , hypoglycemic effect , Cell membrane chromatography
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796582
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