Title of article
Synthesis of linked triple helical DNAs possessing high affinity to triple helical DNA binding protein
Author/Authors
Aya Shibata، نويسنده , , Yoshihito Ueno، نويسنده , , Koichiro Shinbo، نويسنده , , Masayuki Nakanishi، نويسنده , , Akira Matsuda and Fuyuhiko Inagaki، نويسنده , , Yukio Kitade، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
1410
To page
1413
Abstract
The synthesis of triplexes possessing an anthraquinonyl group and composed of branched oligonucleotides (ONs) is described. Binding ability of a triplex-binding protein (MBP-LOR3ARF) to the triplexes was evaluated by an electrophoretic mobility shift assay (EMSA). It was found that the triplex, which has an anthraquinonecarbonyl group at the 5′-end of the third strand and is connected with the pentaerythritol linker, has greater affinity to the protein than an unmodified triplex.
Keywords
Pentaerythritol linker , Anthraquinonyl group , Electrophoretic mobility shift assay , Triple helical DNA , Triplex binding protein
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796589
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