Title of article
4-Aminophenoxyacetic acids as a novel class of reversible cathepsin K inhibitors
Author/Authors
Tsuyoshi Shinozuka، نويسنده , , Kousei Shimada، نويسنده , , Satoshi Matsui، نويسنده , , Takahiro Yamane، نويسنده , , Mayumi Ama، نويسنده , , Takeshi Fukuda، نويسنده , , Motohiko Taki، نويسنده , , Satoru Naito، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
1502
To page
1505
Abstract
We have designed and synthesized a novel series of 3-biphenylamino acid amides as cathepsin K inhibitors based on compound I. In these inhibitors, we have discovered 4-aminophenoxyacetic acids 43 and 47 with good IC50 values, although lipophilic groups are favorable for the hydrophobic S1′ pocket.
Keywords
Cathepsin K inhibitors , 4-Aminophenoxyacetic acids , 3-Biphenylamino acid amides , osteoporosis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796607
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