Title of article
Guanidinylated 2,5-dideoxystreptamine derivatives as anthrax lethal factor inhibitors
Author/Authors
Guan-Sheng Jiao، نويسنده , , Lynne Cregar، نويسنده , , Mark E. Goldman، نويسنده , , Sherri Z. Millis، نويسنده , , Cho Tang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
1527
To page
1531
Abstract
Anthrax lethal factor is a Zn2+-dependent metalloprotease and the key virulence factor of tripartite anthrax toxin secreted by Bacillus anthracis, the causative agent of anthrax. A series of guanidinylated 2,5-dideoxystreptamine derivatives were designed and synthesized as inhibitors of lethal factor, some of which show strong inhibitory activity against lethal factor in an in vitro FRET assay. Preparation and structure–activity relationships of these compounds are presented.
Keywords
Lethal factor inhibitors , metalloprotease , Guanidinylated 2 , 5-dideoxystreptamine derivatives , Anthrax
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796613
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