Author/Authors :
Ranjit C. Desai، نويسنده , , Edward Metzger، نويسنده , , Conrad Santini، نويسنده , , Peter T. Meinke، نويسنده , , James V. Heck، نويسنده , , Joel P. Berger، نويسنده , , Karen L. MacNaul، نويسنده , , Tian-Quan Cai، نويسنده , , Samuel D. Wright، نويسنده , , Arun Agrawal، نويسنده , , David E. Moller، نويسنده , , Soumya P. Sahoo، نويسنده ,
Abstract :
Beginning with a moderately potent PPARγ agonist 9, a series of potent and highly subtype-selective PPARα agonists was identified through a systematic SAR study. Based on the results of the efficacy studies in the hamster and dog models of dyslipidemia and the desired pharmacokinetic data, the optimized compound 39 was selected for further profiling.
