Title of article
Natural and synthetic G-quadruplex interactive berberine derivatives
Author/Authors
Marco Franceschin، نويسنده , , Luigi Rossetti، نويسنده , , Anna D’Ambrosio، نويسنده , , Stefano Schirripa، نويسنده , , Armandodoriano Bianco، نويسنده , , Giancarlo Ortaggi، نويسنده , , Maria Savino، نويسنده , , Christoph Schultes، نويسنده , , Stephen Neidle، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
1707
To page
1711
Abstract
The interaction of the natural alkaloid berberine with various G-quadruplex DNA structures and its ability to inhibit telomerase have been examined and compared with those of a synthetic piperidino derivative and the related compound coralyne. The results show that these molecules have selectivity for G-quadruplex compared to duplex DNA, and that their aromatic moieties play a dominant role in quadruplex binding.
Keywords
G-Quadruplex , telomerase , Alkaloid , Berberine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796649
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