Title of article
Synthesis of Tic-d-Phe Ψ[CH2–CH2] isostere and its use in the development of melanocortin receptor agonists
Author/Authors
Xinrong Tian، نويسنده , , Xuemei Chen، نويسنده , , Lixian Gan، نويسنده , , Jeffery C. Hayes، نويسنده , , Adrian G. Switzer، نويسنده , , Mark G. Solinsky، نويسنده , , Frank H. Ebetino، نويسنده , , John A. Wos، نويسنده , , Beth B. Pinney، نويسنده , , Julie A. Farmer، نويسنده , , Doreen Crossdoersen، نويسنده , , Russell J. Sheldon، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
1721
To page
1725
Abstract
The first synthesis of Tic-d-Phe Ψ[CH2–CH2] isostere is described, which features diastereoselective alkylation of the tricyclic lactam 14. The use of this novel dipeptide isostere in the development of melanocortin agonists has been demonstrated by the synthesis of peptidomimetic 7 and non-peptidic ligand 27. Both compounds displayed significant binding and agonist potency at the MC4R.
Keywords
Melanocortin agonists
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796652
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