Title of article
Synthesis and SAR of substituted tetrahydrocarbazole derivatives as new NPY-1 antagonists
Author/Authors
Romano Di Fabio، نويسنده , , Riccardo Giovannini، نويسنده , , Barbara Bertani، نويسنده , , Manuela Borriello، نويسنده , , Andrea Bozzoli، نويسنده , , Daniele Donati، نويسنده , , Alessandro Falchi، نويسنده , , Damiano Ghirlanda، نويسنده , , Colin P. Leslie، نويسنده , , Angelo Pecunioso، نويسنده , , Giovanna Rumboldt، نويسنده , , Simone Spada، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
1749
To page
1752
Abstract
The SAR of a new series of tetrahydrocarbazole derivatives is described: the appropriate decoration of this template led to the identification of a new class of NPY-1 antagonists showing good in vitro potency and a promising in vivo pharmacokinetic profile in rat.
Keywords
NPY-1 , Antagonists , GPCR
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796658
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