Title of article :
How cyclodextrins can mask their toxic effect on the blood–brain barrier
Author/Authors :
Cécile Binkowski-Machut، نويسنده , , Frédéric Hapiot، نويسنده , , Patrick Martin، نويسنده , , Roméo Cecchelli، نويسنده , , Eric Monflier، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
The toxicity of monosubstituted n-alkyldimethylammonium-β-cyclodextrins (DMA-Cn-CD with n = 2, 4 and 12) towards endothelial cells of an in vitro model of the blood–brain barrier (BBB) was evaluated and compared to that of the native β-CD. DMA-C12-CD was found to be non-toxic below 10 mM due to the self-inclusion of the alkyl chain in the CD cavity. A high percentage of passage (30%) of DMA-C12-CD through the endothelial cells has been measured.
Keywords :
Blood–brain barrier , permeability , endothelial cells , toxicity , Cyclodextrins , In vitro model
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
