Title of article
First dual M3 antagonists-PDE4 inhibitors: Synthesis and SAR of 4,6-diaminopyrimidine derivatives
Author/Authors
Laurent Provins، نويسنده , , Bernard Christophe، نويسنده , , Pierre Danhaive، نويسنده , , Jacques Dulieu، نويسنده , , Véronique Durieu، نويسنده , , Michel Gillard، نويسنده , , Florence Lebon، نويسنده , , Sébastien Lengelé، نويسنده , , Luc Quéré، نويسنده , , BerendJan van Keulen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
6
From page
1834
To page
1839
Abstract
SAR around 4,6-diaminopyrimidine derivatives allowed the discovery of the first potent dual M3 antagonists and PDE4 inhibitors. Various chemical modulations around that scaffold led to the discovery of ucb-101333-3 which is characterized by the most interesting profile on both targets.
Keywords
Muscarinic receptor(s) , Phosphodiesterase , Pyrimidine , COPD
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796674
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