Title of article
Semi-synthetic preparation of the rare, cytotoxic, deep-sea sourced sponge metabolites discorhabdins P and U
Author/Authors
Tanja Grkovic، نويسنده , , Balwinder Kaur، نويسنده , , Victoria L. Webb، نويسنده , , Brent R. Copp، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
3
From page
1944
To page
1946
Abstract
Semi-synthetic routes to the enzyme inhibitory and potently anti-proliferative marine natural products discorhabdins P and U were developed by one-step methylation reactions of discorhabdins C and B, respectively. Two novel semi-synthetic derivatives of discorhabdin U were also prepared, one of which (6) exhibited significant anti-proliferative activity.
Keywords
Discorhabdin , Marine alkaloid , Cytotoxic , Latrunculia
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796697
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