Title of article
A novel series of urea-based peptidomimetic calpain inhibitors
Author/Authors
M. Lee Sanders، نويسنده , , Isaac O. Donkor، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
1965
To page
1968
Abstract
A series of peptide aldehyde derivatives in which the P2 chiral carbon has been replaced with nitrogen were synthesized as urea-based peptidomimetic inhibitors of μ-calpain. The compounds mirrored the general SAR of peptidyl aldehyde calpain inhibitors but displayed greater selectivity for μ-calpain over cathepsin B.
Keywords
Peptidyl aldehyde inhibitors , Calpain inhibitors , Peptidomimetic , Urea-based calpain inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796703
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