Title of article :
Small molecule inhibitors of plasma kallikrein
Author/Authors :
Wendy B. Young، نويسنده , , Roopa Rai، نويسنده , , William D. Shrader، نويسنده , , Jana Burgess-Henry، نويسنده , , Huiyong Hu، نويسنده , , Kyle C. Elrod، نويسنده , , Paul A. Sprengeler، نويسنده , , Mary E. McGrath and Bradley A. Katz، نويسنده , , Juthamas Sukbuntherng، نويسنده , , Joyce Mordenti، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
Plasma kallikrein is a serine protease that is involved in pathways of inflammation, complement fixation, coagulation, and fibrinolysis. Herein, we describe the SAR and structural binding modes of a series of inhibitors of plasma kallikrein as well as the pharmacokinetics of a lead analog 11 in rat.
Keywords :
Plasma kallikrein , p-kallikrein , Serine protease , coagulation , fibrinolysis , Kinin generation , Small molecule inhibitor
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
