Title of article :
Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2
Author/Authors :
Tao Jiang، نويسنده , , Kelli L. Kuhen، نويسنده , , Karen Wolff، نويسنده , , Hong-Yin Chen، نويسنده , , Kimberly Bieza، نويسنده , , Jeremy Caldwell، نويسنده , , Badry Bursulaya، نويسنده , , Tove Tuntland، نويسنده , , Kanyin Zhang، نويسنده , , Donald Karanewsky، نويسنده , , Yun He، نويسنده ,
Abstract :
A series of heterocycle-containing oxindoles was synthesized and their HIV antiviral activities were assessed. Some of these analogs exhibited potent inhibitory activities against both wild-type virus and a number of drug-resistant mutant viruses. In addition, oxindole 9z also showed promising pharmacokinetics.
Keywords :
inhibitor , Oxindole , SAR , AIDS , reverse transcriptase , HIV , Heterocycle
