Title of article
Synthesis and ocular effects of imidazole nitrolic acid and amidoxime esters
Author/Authors
Larisa Oresmaa، نويسنده , , Hanna Kotikoski، نويسنده , , Matti Haukka، نويسنده , , Olli Oksala، نويسنده , , Esko Pohjala، نويسنده , , Heikki Vapaatalo، نويسنده , , Pirjo Vainiotalo، نويسنده , , Paula Aulaskari، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
2144
To page
2147
Abstract
Esters of 1-(H)-imidazole-5-nitrolic acid and 1-methyl-imidazole-5-carboxamide oxime were prepared to study the effect of esterification on the ocular effects of these compounds. Esterifications were performed with acid chloride. Acid chloride also reacts with the ring nitrogen of 1-(H)-imidazole-5-nitrolic acid, but the desired esters could be selectively prepared by adjustment of the reaction conditions. Esterification led to loss of the ocular effects exhibited by the parent compounds.
Keywords
Nitric oxide , intraocular pressure , imidazole , Amidoxime esters , Nitrolic acid esters
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796738
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