Title of article :
Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (−)-dysiherbaine
Author/Authors :
Jamie L. Cohen، نويسنده , , Agenor Limon، نويسنده , , Ricardo Miledi، نويسنده , , A. Richard Chamberlin، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
The design and synthesis of four 2,2-disubstituted dihydrobenzofurans that are structurally related to several glutamate-containing natural products, including (−)-dysiherbaine, is described. Biological evaluation of these analogs shows that one is a KA receptor antagonist and another is an NMDA receptor agonist.
Keywords :
KA receptor agonist , KA reeptor antagonist , Dysiherbaine , NMDA receptor agonist , Scaffold , Excitatory amino acid receptors
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
