Novel skeleton terpenes from Celastrus hypoleucus with anti-tumor activities

Celahypodiol 1, an unusual 17-membered carbon diterpenoid with a novel skeleton, and a new triterpenoid 12-oleanene-3β,6α-diol 2, together with four known compounds furreginol 3, suigol 4, 20(30)-lupene-3β, 29-diol 5, and 20(29)-lupene-1β,3β-diol 6, were isolated from the stalks of Celastrus hypoleucus (Oliv.) Warb. Their structures were established by means of spectroscopic analysis, including 2D NMR. The new compounds exhibited anti-tumor activities against a panel of human tumor cell lines.