Author/Authors :
Luc J. Farmer، نويسنده , , Kristen S. Marron، نويسنده , , Stacie S. Canan Koch، نويسنده , , C.K. Hwang، نويسنده , , E. Adam Kallel، نويسنده , , Lin Zhi، نويسنده , , Alex M. Nadzan، نويسنده , , Dave W. Robertson، نويسنده , , Youssef L. Bennani، نويسنده ,
Abstract :
A new structurally simple series of potent lipophilic aza-retinoids RXR agonists has been developed. SAR studies for the N-alkyl-azadienoic acids described here demonstrate that the RXR activity profile is sensitive to the N-alkyl chain length. Further, we have expanded the work to include azadienoic acids, which exhibited many accessible conformations leading to a better understanding of the SAR around the series.
