Title of article
Aza-retinoids as novel retinoid X receptor-specific agonists
Author/Authors
Luc J. Farmer، نويسنده , , Kristen S. Marron، نويسنده , , Stacie S. Canan Koch، نويسنده , , C.K. Hwang، نويسنده , , E. Adam Kallel، نويسنده , , Lin Zhi، نويسنده , , Alex M. Nadzan، نويسنده , , Dave W. Robertson، نويسنده , , Youssef L. Bennani، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
2352
To page
2356
Abstract
A new structurally simple series of potent lipophilic aza-retinoids RXR agonists has been developed. SAR studies for the N-alkyl-azadienoic acids described here demonstrate that the RXR activity profile is sensitive to the N-alkyl chain length. Further, we have expanded the work to include azadienoic acids, which exhibited many accessible conformations leading to a better understanding of the SAR around the series.
Keywords
RXR selective retinoids , RXR-agonists
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796779
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